Local delivery, or regional chemotherapy as it is otherwise known, is a method of drug delivery to a tumor bearing area through a small catheter placed in the artery supporting the tumor. The majority of chemotherapeutic agents have a low therapeutic index and are found to have limited efficacy when used to treat solid tumors. The primary goal of local (regional) delivery is to deliver a higher concentration and total dose of drug directly to the tumor area than can be safely achieved using systemic infusion. The ability to deliver higher doses locally enable increased drug efficacy while also minimizing toxicity to the rest of the body.
A small-animal study was conducted in which the data shows that it is more effective to deliver medications directly to the tumor site than to deliver systemically. Animals treated with local delivery lived almost 20% longer than those treated systemically.
Small Animal Intratumoral Avastin Report, Thomas C. Chen, Sponsored by PKC
Available upon release of the official publication.
Regional Chemotherapy Improves Outcomes in Patients with Platin-Resistant Ovarian Cancer, Roxanne Nelson, Medscape Medical News, 2008
Pharmacologic Rationale for Regional Drug Delivery, Jerry M. Collins, American Society of Clinical Oncology 1984