SMART Responsive Surgical Device Technology

Providing enhanced tools for the real-time analysis of surgical bioresponse.

Neuro-Kinesis Corporation (NeKC) is the innovator of a variety of surgical medical device platforms all based on its proprietary development of advanced guidance and biosensing response technologies. The goal of NeKC is to expand the ability of the physician to be able to effectively navigate an area of interest with far more accurate telemetry and environment response data then current medical technology provides.

The keys to NeKC’s device technology is grounded in two areas of endeavor that the company has pioneered. The first is in advanced robotic-assisted magnetic guidance control systems. Based on decades of research and success by NeKC’s founders in developing guidance and control systems for aeronautic and defense use, including long histories with the U.S. Department of Defense for the Navy, Army and Air Force as well as aerospace giants like Lockheed Martin, the attention was turned to purposing the advances achieved to re-visioning the way in which surgeons are able to navigate inside the human body. Using an array of magnetic fields, NeKC guidance platform is able to move a specialized catheter along any directional access through a simple adjustment of the opposing magnetic forces. Combined with highly advanced 3-D imaging systems and specialized computer-operated robotics, NeKC’s system can navigate the complex environments of the human body, such as the heart, with far greater precision and repeatability than is currently achievable by manual catheter manipulation.

The second core technology is an adaptation of a proprietary biosensor technology. By fitting the micro-chip printable biosensor into an array of specialized surgical tools, NeKC can provide a surgeon real-time readings of tissue viability, neuro-electrical activity, fluid and mass density, and biomarker composition. This allows a surgeon to know instantly the bioresponse a procedure is having as well as the best path and method to navigate to an area of interest.

By combining advanced guidance and ground-breaking bioresponse technologies into innovative new surgical device platforms, NeKC is rapidly changing the face of surgical diagnostic care.

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Neuro-Kinesis has proposed a variety of potential product candidates for its Intelligent Bioresponse Surgical Device technology including the following:

CGCI™
The Neuro-Kinesis Catheter Guidance Control and Imaging (CGCI) system uses an array of eight magnetic lobes for the precision placement of specialized catheters inside a human body. By adjusting the output of the electromagnets in the array, the focal point can be moved in any direction in 3-dimensional space.

MOSFET™ CATHETER
MOSFET™, which stands for Metal-Oxide Semiconductor Field-Effect Transistor, represents a quantitative leap-forward in surgical catheter technology for procedures such as ablation and mass biopsy. MOSFET is the first intelligent catheter system which measures the electrical potential of a cell, tissue or organ in the body thus enabling the physician to visualize the environment they are operating in a much less invasive manner with far greater resolution and in a 3-dimensional landscape.

SMART BRAIN RETRACTOR
The Smart Brain Retractor (SBR) is designed to facilitate the ability of a neurosurgeon to navigate their path to a targeted site within a patient’s brain tissue by providing real-time feedback on the impact a procedure is having on vital tissue statuses such as blood-flow, connective pressures, temperature and electrical impedance in order to avoid potential neurological tissue trauma.

All of Neuro-Kinesis’ product candidates deliver next-generation advances in real-time biologic to digital data analysis feedback, in order to optimize the efficacy of the surgical physician to more effectively navigate the human body during operative procedures. In addition each technology offers unique improvements to existing platforms:

CGCI^TM

Precise navigational control using magnetic field array.
Consistent and accurate target acquisition.
Increased catheter stability.
Real-time 3D imaging.
Robotic-assisted control allows for automated return to target catheter positioning.
Transmurality of ablations.
Shorter procedure time.
Lower radiation exposure.
Increased safety and efficacy.

MOSFET^TM

Source-point signal amplifier to eliminate signal degradation.
A proprietary sensor array that is much more efficient at distinguishing relevant data from
extraneous noise.
Interpretation of resulting data at the sensor point instead of post signal processing.
Conversion of the analog information to true digital information after processing in order to
transmit the signal readings in a high-definition, uncompromised language back to the physician.
Adaptable tip can fit most modern catheter designs.

SBR^TM

Sensor pads can monitor an array of vital biologic data including tissue pressures, temperature, electrical impedance and blood flow.
Unique sheath design can fit most existing brain retractor devices.
Data is passed in real-time back to the treating surgical time dramatically lessening the potential for possible tissue damage, hypoxic-ischemia or vascular damage.

Application for Neuro-Kinesis’ unique technology platforms is ever-expanding and at each step is providing game-changing breakthroughs in the mitigation, treatment and cure for a variety of critical neuro-pathologic health issues. Neuro-Kinesis also sees potential application of its technology for other disease treatment areas where guided and targeted navigation combined with real-time biological data analysis can dramatically elevate positive outcomes.

The following are the first-focus areas of interest for Neuro-Kinesis’ current technology platforms:

For CGCI^TM – Coronary mapping, atrial fibrillation ablation, cardio-vascular biopsy.

For MOSFET^TM –Renal denervation, neuromodulation for treatment of Parkinson’s disease, essential tremor issues, primary dystonia.

For SBR^TM– Cranial biopsy, tumor resection, vascular cauterization.

CONTACT NEURO-KINESIS

6053 W Century Blvd. Suite 1000
Los Angeles, CA 90045-6400
T: 310-641-2700
F: 310-641-2702
E: info@neuro-kinesis.com